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Literature summary extracted from

  • Kacher, Y.; Golan, A.; Pewzner-Jung, Y.; Futerman, A.H.
    Changes in macrophage morphology in a Gaucher disease model are dependent on CTP:phosphocholine cytidylyltransferase alpha (2007), Blood Cells Mol. Dis., 39, 124-129.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.15 conduritol-B-epoxide treatment of macrophages with 0.5 mM conduritol-B-epoxide results in elevated activity of CCT Mus musculus
2.7.7.15 conduritol-B-epoxide treatment of macrophages with 0.5 mM conduritol-B-epoxide results in elevated activity of CCT Homo sapiens

Application

EC Number Application Comment Organism
2.7.7.15 medicine possible role for macrophage CCTalpha in Gaucher disease pathology Mus musculus
2.7.7.15 medicine possible role for macrophage CCTalpha in Gaucher disease pathology Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Homo sapiens
-
-
-
2.7.7.15 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.15 macrophage CCTalpha is the major CCT isoform in macrophages Mus musculus
-
2.7.7.15 macrophage CCTalpha is the major CCT isoform in macrophages Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + choline phosphate
-
 Mus musculus diphosphate + CDP-choline
-
 ?
2.7.7.15 CTP + choline phosphate
-
 Homo sapiens diphosphate + CDP-choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.15 CCTalpha isozyme Mus musculus
2.7.7.15 CCTalpha isozyme Homo sapiens
2.7.7.15 CTP:phosphocholine cytidylyltransferase alpha
-
 Mus musculus
2.7.7.15 CTP:phosphocholine cytidylyltransferase alpha
-
 Homo sapiens